How does thalassemia affect the skeletal system Essay

How does thalassemia affect the skeletal system - Essay Example Thalassemia is a hereditary disorder characterized by a diminished or a malfunction of the production of hemoglobin; a blood protein that transports oxygen to the tissues, which results from the mutation of the manufacture of hemoglobin primarily because of the abnormality of the bones and the enlargement of the spleen. Anemia is a good example that portrays severe cases of Thalassemia; bone and growth deformities, defects and hemosiderosis (Barber & Stringer, 2011). The most common Thalassemias are alpha-Thalassemia and beta-Thalassemia whose frequency of occurrence is around 1.7% worldwide. Alpha-Thalassemia comes from the abnormal production of the ÃŽ ±-globin chain while ÃŽ ²-Thalassemia is from the ÃŽ ²-globin chain (Barber & Stringer, 2011). Alpha-Thalassemia affects mainly people from Africa and South-East Asia while beta-Thalassemia is prevalent among people from the Mediterranean, Africa, and South-East Asia. The predominance of ÃŽ ²-Thalassemia is higher in areas where malaria is or was once an endemic. Severe changes occur on the calvarium due to porotic hyperostosis as shown in figure 1 below. This manifests extensively on the frontal portion including the inferior portion, the parietals and the squamous of the occipital through porosis (Lagia et al., 2007). Due to Thalassemia, patients often experience extensive pitting in the posterior portion of the skull, which includes the parietal and occipital bones as shown in figure 3. There is also mild pitting of the frontal bone and the orbital roof as demonstrated in figure 2. For this reason, the cranial bones become thicker than usual, wavering from typical 4.5mm to a maximum of 10mm in thickness (Filon et al., 1995). The expanded diploe can be seen on the external surface, which becomes eroded over time. The trabeculae of the diploe become increasingly reduced in number, accompanied by the thickening and radial arrangement of the trabeculae that are left;

LAW OF BUSINESS LEASES Term Paper Example | Topics and Well Written Essays - 2250 words - 1

LAW OF BUSINESS LEASES - Term Paper Example This holistic way covers the nurses’ responsibility and attitude when providing emotional support; when providing support in the form of information and their capacity to provide practical support (Liu, Mok & Wong, 2006). Jean Watson, an expert in the field of nursing, emphasizes that the concept of caring is more of a science than an art or a professional skill (Watson, 2003). Watson defines caring as the science that entails a human science oriented humanitarian process of taking care of others, in a manner which demonstrates the evidence of arts, science and humanities in the delivery of care services (Watson, 2003). The Macmillan dictionary (online) defines care as, being interested in someone and wanting them to be well and happy (Care [Def. 1], 2014). The word caring is a derivative of the word ‘care’, which came from the old English world caru, cearu – meaning anxiety, sorrow, and grief. The word is also believed to have emanated from the Proto-Germanic word ‘karo’, which means severe mental attention or the reality of mental burdens. The word is believed to have evolved from the different origins in a variety of ways, including that in English it implies the lamentation, cry or the grief of a person. From the world of poetry – the concept of caring has been communicated and emphasized by different writers, including the writing of the physician-poet William Carlos; the writer emphasizes the importance of caring and the way it is communicated through poetry. The lines drawn from the poem present a paradox which is very useful to the experience of clinicians, especially those who care for the dying and the terminally ill. From the first statement, â€Å"it is difficult – to get the news from poems† is self-explanatory; the statement appears to emphasize the fact that poetry offers people little or no hard data (Coulehan & Clary, 2005). The emphasis is that poetry does not provide useful information about recent

Supermarkets in UK Literature review Example | Topics and Well Written Essays - 3000 words

Supermarkets in UK - Literature review Example The researcher aims to evaluate and present academic journals that relate to the topic. The first academic article that relates to my topic is UK Supermarket Space Race Faces Scrutiny by Andrea Felsted. â€Å"The main beneficiaries in the retail grocery sector of this drive to economies have been those large-scale supermarkets that have pushed everyday low prices, while some of the more basic bargain retailers have also seen benefits†. The article Supermarkets – The New Drivers of Urban Growth published in the journal says that, Supermarkets have turned out to be one of the main players in shaping and building places. The author summaries in the article are that, retailers don’t desire to construct a supermarket these days. â€Å"While the economic downturn has impacted heavily upon most development, the major retailers have gone from strength to strength. Supermarkets are increasingly being built on prime sites in an urban setting, rather than out of town, and investment in the site goes well beyond building a big retail shed† Mintel in his book says that it was a very rough year in 2010 for grocery retailers, due to clients switching to extremely competitive discount food dealers, and that they paid more attention on wasting food. According to Alexandru M. Degeratu in his article called, Consumer Choice Behavior in Online and Traditional Supermarkets: The Effects of Brand Name, Price, and other Search Attributes, says that, there is rising interest or attention in understanding the results of computer mediated shopping atmospheres. A subject of particular interest to equally academics and practitioners is in determining whether there are methodical dissimilarities in customer choice behavior among regular and online (offline) storerooms, and if there are dissimilarities, in understanding the causes for these differences. â€Å"Advertising induces brand loyalty in consumers who would otherwise purchase the cheapest alternative on t he market.†4 According to Helen E Perriman in his article, THE IMPACT OF THE GLOBAL FINANCIAL CRISIS ON CONSUMER BEHAVIOUR, behavior of the consumer is influenced by both interior features and external features that characterize the atmosphere in which the person behavior takes place. (Helen E Perriman 2010). Andy Wood in his article called, Shopper behaviour as the UK Exits Recession, talks about consumer’s supermarket shopping behavior during recession. According to him, one of the most precious tools in every retail grocery market chaos is the programmes related to consumer loyalty. Whereas in the previous year, the market share of the Tesco dipped in the face of customers going down the bazaar looking for superior deals, so the marketplace leader has organized to turn various things around. (Andy Wood 2010). The major beneficiaries in the

Mohrs Circle and Strain Gauge Rosette Lab Report

Mohrs Circle and Strain Gauge Rosette - Lab Report Example An aluminium alloy beam, clamped at one end within a rig containing a cam whose full-range rotation leads to a repeatable tip deflection of = 0.5" = 12.7 mm, as shown in Figure1. The beam has dimensions as follows: breadth b = 25.4 mm, depth d = 6.35 mm and length (to the cam) L = 254 mm. Three strain gauges are mounted on the upper surface at 94 mm from the clamped end; these gauges are mounted at 15, 45, and 75 with respect to the longitudinal, x-axis, of the beam, as shown in Figure 2. Each of these gauges can be selected using a switchboard, to be one arm of a Wheatstone bridge arrangement [1 research and give reference ], with a dummy strain gauge providing temperature compensation. The Wheatstone bridge is a divided bridge circuit used to measure electrical resistance; these minute changes in resistance correspond to strain in a strain gage in what is known as a bonded resistance strain gage [2] From a), determine the principal strains I and II, as well as the direction of maximum shear strain. Also, determine the value of Poisson's ratio, , for the material. In this experiment I should theoretically be equal and in the direction of x. Inevitably there will be experimental errors so your result may be different. In the discussion section (6.), discuss possible reasons why the maximum strain obtained may not be predicted to occur in the x-direction,

Philosophy theory Essay Example | Topics and Well Written Essays - 1000 words

Philosophy theory - Essay Example The concept of absurd has a rather weighty importance in the work of Kierkegaard. Kierkegaard considers the theory of absurd in several of his works, but it occupies a special role in his work Fear and Trembling. Here, speaking from a position of criticism of Christianity, Kierkegaard considers the biblical story when Abraham was asked by God to sacrifice his son to Him. For Kierkegaard, this is an example of the absurdity of human existence, based on lack of freedom. Kierkegaard sees the faith of Abraham as a paradox as it is able to convert a murder into the sacred and charitable act. Kierkegaard, however, does not diminish the importance of faith. On the contrary, he emphasized that faith is transcendent and therefore is absurd. Faith in God is absurd because it cannot be explained by means of logic, however, it is effective by giving people the spiritual strength. Thus, the absurd is an inability to logically comprehend faith in God, while it is able to provide moral support. Feuerbach demonstrates a critical attitude to religion, because he is convinced that it is the result of the alienation of human qualities such as kindness, compassion, etc. Religion arose when people began to ascribe to God the qualities that belong to the people. The philosopher believes that a man is in himself a divine being, and it is a man (not the transcendent God) who should be deified. Thus, in the concept of Feuerbach, a divine being is a human being who deserves to be erected on a pedestal of God. People should treat each other as if each of them is God. Thus, the interaction between people should be based on the principles of equality, justice, and mutual aid. In this respect, love also plays a particularly important role as a force that unites people. In his works, Nietzsche provided a strict demarcation between the weak and strong cultures, each of which

Bio-Terrorism Research and Development Essay Example | Topics and Well Written Essays - 750 words

Bio-Terrorism Research and Development - Essay Example These pathogens have high probabilities of bioterrorism use because they can be disseminated fast and without difficulty; would simply need minimal amounts to cause and spread diseases; and would cause high levels of morbidity and mortality (Perlin, 2008). Category A agents, being the highest risk agents, are top priority in research efforts. Category B agents create the second highest threat.  Category C agents are the emerging communicable disease hazards (â€Å"Potential Bioterrorism Agents,â€Å" 2010). Biological agents such as anthrax, botulism, plague, smallpox, tularemia, and viral hemorrhagic fevers (â€Å"NIAID report claims great progress in biodefense research,† 2010), are cheap substitutes to conventional weapons. Preferred by terrorists, these pathogens have easy accessibility; rapid production and distribution; low detection and high potentials for causing national disturbance (â€Å"Potential Bioterrorism Agents,â€Å" 2010). Since 2002, the National Institute of Allergy and Infectious Diseases (NIAID) has shown remarkable progress in the development of measures to counteract bioterrorist attacks. Basic research programs comprise the latest designation and financial support of eight regional academic centers for biodefense research and rising transmittable diseases. All strains of pathogen genomes with high-risk for bioterror use are sequenced and determined of possible viral and protozoal bioterrorism infection. Researchers are given grants to study the deterrence, identification, and cure of diseases caused by bioweapons. The NIAID research targets on the development of effective vaccines and precise diagnosis (â€Å"NIAID report claims great progress in biodefense research,† 2010). Mucosal immunities are studied on areas of infection, such as the respiratory organs and oral passages since potential bioweapons are most likely to infect those areas (â€Å"Introduction to Biodefense Research,â₠¬  2010). Proposed efforts to

Financial Crisis and Recovery Essay Example | Topics and Well Written Essays - 250 words

Financial Crisis and Recovery - Essay Example As a result of higher spending, the US had significantly expanded the economy to be much longer and stronger than before. However, it can be argued that the structural change in the US economy did not influence the recessionary periods to be shorter and milder (Tseng, â€Å"Follow Canada? Only at Your Own Risk†) For instance, the US economy had to witness eleven recessionary instances since the great depression. Consequently, the average GDP growth for the ten recessionary instances until 2001 was recorded as -0.7% which signifies that the economic recession in the US was not at all mild. However, the records depict that the longest recession was witnessed by the US in 1973 and 2007 which continued for two years. This signifies that even though the US economic recession was shorter, the frequency of such instances had increased substantially (Federal Reserve Bank of Atlanta, â€Å"The Financial Crisis and Recovery: Why so Slow?†). According to Keynesian theory, when the spending of an economy increases, the earning of people also increases. The basis of the theory is that whenever an individual spends a portion of his/her earning, it is likely to support the earning of other individuals (Greiner, â€Å"Models of Economic Growth†). This cycle of earning and spending can enable an economy to sustain its expansion. In response to the reason for slow growth of economy according to Keynesian theory, it can be stated that after the recession of 2007, the banks and the financial institutions had faced significant problems which had interrupted the flow of credit. In order to deal with the economic recession, the financial regulations in different nations have become much tighter and stricter than before, resulting in low access to finance.